Charlie (Jennifer Lopez) is looking for a nice guy who will appreciate her, as well as her myriad of interests and jobs. From walking dogs to painting to designing clothes to answering phones at a doctor's office, Charlie does it all. Keith (Michael Vartan) seems to fit the bill as a perfect match for her: he's charming, handsome, a successful doctor, and he is completely smitten with her. And now, he has proposed and wants to marry her. There's just one problem: his mother, Viola (Jane Fonda), is a nightmare. A legendary television journalist who has an on-air breakdown after being replaced by a much younger woman, Viola virtually lives for Keith, especially now that her career is apparently over. She doesn't think Charlie is good enough for her son, and she plans to do everything she can to break them up.
Enlisting the help of her assistant, brutally honest Ruby (Wanda Sykes), Viola plots ways to drive Charlie crazy--and get her away from her son. She feigns illness, belittles her future daughter-in-law's jobs, and invites her son's old flame to visit at inopportune moments, among other things. But Viola underestimates Charlie, who isn't about to give up a happy future with Keith without a fight. Directed by Richard Luketic (LEGALLY BLONDE, WIN A DATE WITH TAD HAMILTON!), MONSTER-IN-LAW marks Fonda's return to the big screen following a 14-year absence. Elaine Stritch appears as Viola's own former monster-in-law.